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Product Description
– Fenoldopam (SKF 82526) hydrochloride is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam hydrochloride shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis[1][2][3].
Web ID
– HY-110021
Shipping
– Room temperature
Molecular Formula
– C16H17Cl2NO3
References
– [1]Yan Zheng, et al. Identification of fenoldopam as a novel LSD1 inhibitor to abrogate the proliferation of renal cell carcinoma using drug repurposing strategy. Bioorg Chem. 2021 Mar;108:104561.|[2]Yuta Fujii, et al. Detection of fenoldopam-induced arteritis in rats using ex vivo / in vivo MRI. Toxicology Reports, Volume 9, 2022, Pages 1595-1602.|[3]A Grenader, et al. Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J Pharmacol Exp Ther. 1991 Jul 1;258(1):193-8.
CAS Number
– 181217-39-0
Molecular Weight
– 342.22
SMILES
– ClC1=C(CCNCC2C3=CC=C(C=C3)O)C2=CC(O)=C1O.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Dopamine Receptor;Histone Demethylase
Pathway
– Apoptosis;Epigenetics;GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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