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FASN-IN-4 (tosylate)
$228 – $2,400
Products Details
Product Description
– FASN-IN-4 tosylate is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29)[1]. FASN-IN-4 tosylate also inhibits SARS-CoV-2 with an EC50 of 18.6 nM[2].
Web ID
– HY-12648A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C33H35N3O7S2
Citations
– Sci China Life Sci. 2021 May 27;1-21.|Cell Biosci. 2022 Sep 16;12(1):158.|Nat Metab. 2021 Sep 27;1-10.
References
– [1]Junjun Chu, et al. Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. Nat Metab. 2021 Nov;3(11):1466-1475.|[2]Nicholas D. Adams, et al. Fatty acid synthase inhibitors. WO2012064642A1.
CAS Number
– 2095432-57-6
Molecular Weight
– 649.78
Compound Purity
– 99.84
SMILES
– OS(C1=CC=C(C)C=C1)(=O)=O.O=C2COC3(CCN(S(=O)(C4=CC=C(C5=CC=C6C=CC=NC6=C5)C=C4)=O)CC3)CN2C7CC7
Clinical Information
– No Development Reported
Research Area
– Infection; Metabolic Disease
Solubility
– DMSO : 12.5 mg/mL (ultrasonic)
Target
– Fatty Acid Synthase (FASN);SARS-CoV
Pathway
– Anti-infection;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
