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Products Details
Product Description
– FAP-PI3KI1 is a fibroblast-activated protein (FAP)-targeted PI3K inhibitor that selectively targets FAP-expressing human idiopathic pulmonary fibrosis (IPF) cells and effectively inhibits collagen synthesis and reduces collagen deposition[1].
Web ID
– HY-145358
Shipping
– Room temperature
Molecular Formula
– C52H48F4N10O12S3
References
– [1]Suraj U Hettiarachchi, et al. Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models. Sci Transl Med. 2020 Oct 28;12(567):eaay3724.
CAS Number
– 2415941-98-7
Molecular Weight
– 1177.19
SMILES
– O=C(N1[C@@H](CC(F)(C1)F)C#N)[C@H](C)NC(C2=CC=NC(CNC(CCC(N[C@H](C(O)=O)CSSCCOC(OCC3=NC=C(C4=CC=NC5=C4C=C(C6=CN=C(OC)C(NS(=O)(C7=C(C=C(C=C7)F)F)=O)=C6)C=C5)C=C3)=O)=O)=O)=C2)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– PI3K
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
