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Products Details
Product Description
– Famitinib (SHR1020) malate, an orally active multi-targeted kinase inhibitor, inhibits the activity of c-kit, VEGFR-2 and PDGFRβ with IC50 values of 2.3 nM, 4.7 nM and 6.6 nM, respectively. Famitinib malate induces cell apoptosis. Famitinib malate exerts powerful antitumor activity in human gastric cancer cells and xenografts, it can be used for the research of cancer[1][2].
Web ID
– HY-108713A
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C27H33FN4O7
References
– [1]Liguang Lou, et al. Abstract 3604: Preclinical antitumor study of famitinib, an orally available multi-targeted kinase inhibitor of VEGFR/PDGFR/c-Kit in phase I clinical trials.|[2]Sai Ge, et al. Famitinib exerted powerful antitumor activity in human gastric cancer cells and xenografts. Oncol Lett. 2016 Sep;12(3):1763-1768.
CAS Number
– 1256377-67-9
Molecular Weight
– 544.58
SMILES
– O=C1C2=C(NC(/C=C3C(NC4=C3C=C(F)C=C4)=O)=C2C)CCN1CCN(CC)CC.O[C@H](C(O)=O)CC(O)=O
Clinical Information
– Phase 3
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;PDGFR;VEGFR
Isoform
– PDGFRβ;VEGFR2/KDR/Flk-1
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
