Download Files:
Famitinib
$590 – $4,900
Products Details
Product Description
– Famitinib (SHR1020), an orally active multi-targeted kinase inhibitor, inhibits the activity of c-kit, VEGFR-2 and PDGFRβ with IC50 values of 2.3 nM, 4.7 nM and 6.6 nM, respectively[1]. Famitinib exerts powerful antitumor activity in human gastric cancer cells and xenografts. Famitinib triggers apoptosis[2].
Web ID
– HY-108713
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C23H27FN4O2
References
– [1]Liguang Lou, et al. Abstract 3604: Preclinical antitumor study of famitinib, an orally available multi-targeted kinase inhibitor of VEGFR/PDGFR/c-Kit in phase I clinical trials.|[2]Sai Ge, et al. Famitinib exerted powerful antitumor activity in human gastric cancer cells and xenografts. Oncol Lett. 2016 Sep;12(3):1763-1768.
CAS Number
– 1044040-56-3
Molecular Weight
– 410.48
Compound Purity
– 98.43
SMILES
– O=C1C2=C(NC(/C=C3C(NC4=C3C=C(F)C=C4)=O)=C2C)CCN1CCN(CC)CC
Clinical Information
– Phase 3
Research Area
– Cancer
Solubility
– DMSO : 4.17 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Apoptosis;PDGFR;VEGFR
Isoform
– PDGFRβ;VEGFR2/KDR/Flk-1
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
