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Products Details
Product Description
– Compound 26F not only optimized the effective inhibitory enzyme (ic50= 28.2 nm), but also showed relatively less cytotoxicity (ic50= 3.32 μ M) And induced MDA-MB-231 cell apoptosis in a dose-dependent manner, effectively blocking MDA-MB-231 cells in g0/g1 phase.
Web ID
– HY-146203
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C25H24FN5O2S
References
– [1]Wang R,et al. Design, synthesis, biological evaluation and molecular docking study of novel thieno[3,2-d]pyrimidine derivatives as potent FAK inhibitors. Eur J Med Chem. 2020 Feb 15;188:112024.
CAS Number
– 2410056-27-6
Molecular Weight
– 477.55
SMILES
– COC1=CC=CC=C1C2=CSC3=CN=C(N=C32)NC4=CC(F)=C(C=C4)C(NC5CCNCC5)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– FAK
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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