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Products Details
Product Description
– FAK-IN-16 (compound OXA-11) is an orally active, selective focal adhesion kinase (FAK) inhibitor with an IC50 of 1.2 pM. FAK-IN-16 inhibits FAK phosphorylation at pFAK[Y397] and pFAK[Y861]. FAK-IN-16 slows tumor growth and reduces tumor vascularity, invasion. FAK-IN-16 potentiates effects of Cisplatin (HY-17394) on tumor cell proliferation and apoptosis in vitro and anti-tumor actions in mice[1].
Web ID
– HY-117836
Shipping
– Room temperature
Molecular Formula
– C37H49F3N7O5P
References
– [1]Ingrid Moen, et al. Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic neuroendocrine tumors. Clin Exp Metastasis. 2015 Dec;32(8):799-817.
CAS Number
– 1257994-15-2
Molecular Weight
– 759.80
SMILES
– COC1=CC(CP(OCC)(OCC)=O)=CC=C1NC2=NC=C(C(F)(F)F)C(NC3=CC=C([C@H]4CC[C@H](N5CCN(C)CC5)CC4)C(CN6C)=C3C6=O)=N2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– FAK
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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