Facinicline (hydrochloride)

$300$2,200

Products Details

Product Description

– Facinicline hydrochloride (RG3487 hydrochloride) is an orally active nicotinic α7 receptor partial agonist, with a Ki of 6 nM for α7 human nAChR. Facinicline hydrochloride (RG3487 hydrochloride) improves cognition and sensorimotor gating in rodents. Facinicline hydrochloride (RG3487 hydrochloride) shows high affinity (antagonist) to 5-HT3Rs with a Ki value of 1.2 nM[1].

Web ID

– HY-108057A

Storage Temperature

– 4°C (Powder, sealed storage, away from moisture)

Shipping

– Room Temperature

Applications

– Neuroscience-Neuromodulation

Molecular Formula

– C15H19ClN4O

References

– [1]Tanya L Wallace, et al. RG3487, a Novel Nicotinic α7 Receptor Partial Agonist, Improves Cognition and Sensorimotor Gating in Rodents. J Pharmacol Exp Ther. 2011 Jan;336(1):242-53.

CAS Number

– 677305-02-1

Molecular Weight

– 306.79

Compound Purity

– 99.93

SMILES

– [H]Cl.O=C(C1=NNC2=C1C=CC=C2)N[C@@H]3CN4CCC3CC4

Clinical Information

– No Development Reported

Research Area

– Neurological Disease

Solubility

– DMSO : 125 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)

Target

– 5-HT Receptor;nAChR

Isoform

– 5-HT3 Receptor

Pathway

– GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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