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Product Description
– Fabesetron (FK1052) is an orally active 5-HT3 receptor antagonist with 5-HT4 receptor antagonistic activity. Fabesetron (FK1052) can be used in the study for both acute and delayed emesis induced by cancer chemotherapy[1][2].
Web ID
– HY-105201
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H19N3O
References
– [1]M Kadowaki, et al. Effect of FK1052, a potent 5-hydroxytryptamine3 and 5-hydroxytryptamine4 receptor dual antagonist, on colonic function in vivo. J Pharmacol Exp Ther. 1993 Jul;266(1):74-80.|[2]Hiroe Nakayama, et al. Antiemetic activity of FK1052, a 5-HT3- and 5-HT4-receptor antagonist, in Suncus murinus and ferrets. J Pharmacol Sci. 2005 Aug;98(4):396-403.
CAS Number
– 129300-27-2
Molecular Weight
– 293.36
Compound Purity
– 95.72
SMILES
– O=C1N2C3=C(C=CC=C3)C(C)=C2CC[C@@H]1CC4=C(NC=N4)C
Clinical Information
– No Development Reported
Research Area
– Cancer; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– 5-HT Receptor
Isoform
– 5-HT3 Receptor;5-HT4 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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