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Products Details
Product Description
– EZH2-IN-9 is a potent inhibitor of EZH2. EZH2 overexpression or mutations in the SET region (Y641F, Y641N, A687V, A677G point mutations) all lead to abnormal elevation of H3K27me3 and promote the growth and development of many types of tumors, such as breast cancer, prostate cancer, leukemia, etc. EZH2-IN-9 has the potential for the research of cancer diseases (extracted from patent WO2021180235A1, compound 17)[1].
Web ID
– HY-144094
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C28H32ClF2N3O5S
References
– [1]Li Yao, et al. Zeste enhancer homologue 2 inhibitor and its use. Patent WO2021180235A1.
CAS Number
– 2700897-24-9
Molecular Weight
– 596.09
SMILES
– CC1=C2C(OC(O2)([C@]3([H])CC[C@H](CC3)C(N4CC(F)(C4)F)=O)C)=C(C=C1C(NCC5=C(C=C(NC5=O)C)SC)=O)Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Histone Methyltransferase
Isoform
– EZH2
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
