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Products Details
Product Description
– EZH2-IN-17 (compound 28) is a potent and orally active EZH2 inhibitor with an IC50 value of 0.95 nM. EZH2-IN-17 exhibits high anti-proliferation activity against different lymphoma cell lines including WSU-DLCL2, Pfeiffer and Karpas-422 (IC50 values of 2.36 nM, 1.73 nM, and 1.82 nM, respectively)[1].
Web ID
– HY-149726
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C36H46N4O4
References
– [1]Xin Xu, et al. Conformationally constrained potent inhibitors for enhancer of zeste homolog 2 (EZH2). Bioorg Med Chem Lett. 2023 Nov 11:129558.
CAS Number
– 2489672-09-3
Molecular Weight
– 598.77
SMILES
– O=C1C(CNC(C2=CC(C3=CC=C(C(N4CCOCC4)CC5)C5=C3)=CC(N(C6CCOCC6)CC)=C2C)=O)=C(C)C=C(C)N1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Histone Methyltransferase
Pathway
– Epigenetics
Product type
– Reference compound
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