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Exatecan Intermediate 5
$235 – $652
Products Details
Product Description
– Exatecan Intermediate 5 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 5 can be used to synthesize Antibody-Drug Conjugates (ADCs).
Web ID
– HY-43564
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C15H17FN2O3
References
– [1]Xu, et al. Preparation of exatecan intermediate and its application. China, CN115701419 A. 2023-02-10.|[2]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82.
CAS Number
– 143655-70-3
Molecular Weight
– 292.31
Compound Purity
– 99.47
SMILES
– FC1=CC(NC(C)=O)=C(C(C(NC(C)=O)CC2)=O)C2=C1C
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Topoisomerase
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
