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Etomoxir (sodium salt)
$70 – $550
Products Details
Product Description
– Etomoxir((R)-(+)-Etomoxir) sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig[1].
Web ID
– HY-50202A
Storage Temperature
– -20°C (Powder, protect from light, stored under nitrogen)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C15H18ClNaO4
Citations
РAntimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e01659-17. |Cell Death Dis. 2022 Mar 11;13(3):229.|Cell Metab. 2022 Sep 7;S1550-4131(22)00359-X.|Cell Rep. 2019 Apr 2;27(1):226-237.e4.|J Invest Dermatol. 2023 Mar 30;S0022-202X(23)01952-8.|Mol Cell. 2020 Oct 1;80(1):43-58.e7.|Mol Cell. 2022 Jun 15;S1097-2765(22)00539-1.|Redox Biol. 2018 Jul;17:180-191.|Research Square Preprint. 2023 Aug 1.|Acta Biomater. 2022 Jul 30;S1742-7061(22)00453-6.|Biochem Biophys Res Commun. 2017 Feb 5;483(2):860-866.|Biochem Biophys Res Commun. 8 October 2021.|bioRxiv. 2021 Mar 8.|bioRxiv. 2023 Apr 17.|bioRxiv. 2023 Nov 17.|Cancer Cell Int. 2023 May 9;23(1):87.|Cancer Res. 2023 Jun 5;CAN-23-1006.|Cell Death Dis. 2023 Feb 15;14(2):125.|Cell Death Dis. 2023 Oct 6;14(10):653.|Cell Metab. 2023 Nov 16:S1550-4131(23)00386-8.|Cell Physiol Biochem. 2018;48(6):2318-2336. |Cell Prolif. 2021 Sep 25;e13134.|Cell Rep. 2021 Sep 7;36(10):109659.|Clin Transl Med. 2022 Sep;12(9):e1061.|Commun Biol. 2022 Dec 7;5(1):1340.|Food Chem Toxicol. 2022 Oct 5;113450.|Free Radic Biol Med. 2019 Sep;141:372-382.|Free Radic Biol Med. 2022 Aug 8;190:94-104.|Front Immunol. 2022 Mar 10;13:771732.|Front Oncol. 2021 Apr 22;11:665763.|Front Oncol. 2021 Apr 6.|Front Pharmacol. 2022 May 16;13:848957.|Hepatology. 2022 Jan 14.|Infect Genet Evol. 2020 Nov;85:104552.|Int J Biol Sci. 2021 Oct 11;17(15):4207-4222.|Int J Biol Sci. 2022 Mar 14;18(6):2484-2496.|J Biomed Mater Res A. 2022 Aug;110(8):1448-1459.|J Cell Biol. 2022 Dec 5;221(12):e202207022.|J Cell Sci. 2022 Jul 1;jcs.259090.|J Invest Dermatol. 2023 Mar 30;S0022-202X(23)01952-8.|J Orthop Surg Res. 2023 May 26;18(1):386.|Nat Commun. 2021 Jun 16;12(1):3660.|Nat Commun. 2022 Jun 17;13(1):3486.|Oncol Rep. 2023 Jul;50(1):141.|Oncol Rep. 2023 May 29.|Oncotarget. 2016 Oct 11;7(41):67071-67086.|Pharmacol Res. 2021 Jul 31;105796.|Proc Natl Acad Sci U S A. 2021 Nov 16;118(46):e2105950118.|Redox Biol. 2018 Oct;19:412-428. |Redox Biol. 2021 Jul 26;46:102082.|Research Square Preprint. 2020 Sep.|Research Square Preprint. 2022 Feb.|Sci Adv. 2023 Apr 14;9(15):eadf8522.|Sci Immunol. 2023 Sep 29;8(87):eabq2424.|Science Partner Journals. 2023 Feb 14.|SSRN. 6 Dec 2022.|Theranostics. 2020 May 16;10(14):6483-6499. |Universidade de Ṣo Paulo. Ribeiṛo Preto, 2021.|Vet Microbiol. 2023 Nov 30:288:109932.
References
– [1]Roddy S O’Connor, et al. The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations.Sci Rep. 2018 Apr 19;8(1):6289.|[2]Fred Y Xu,et al.Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells.J Lipid Res. 2003 Feb;44(2):415-23.|[3]Jun Li, et al. FFA-ROS-P53-mediated mitochondrial apoptosis contributes to reduction of osteoblastogenesis and bone mass in type 2 diabetes mellitus.Sci Rep. 2015 Jul 31;5:12724.|[4]Joost J F P Luiken, et al. Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates.Biochem J. 2009 Apr 15;419(2):447-55.
CAS Number
– 828934-41-4
Molecular Weight
– 320.74
Compound Purity
– 99.73
SMILES
– ClC1=CC=C(OCCCCCC[C@@]2(CO2)C(O[Na])=O)C=C1
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Cancer
Solubility
– DMSO : 50 mg/mL (ultrasonic)|H2O : 5 mg/mL (ultrasonic)
Target
– Apoptosis
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
