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Etilevodopa (hydrochloride)
$50 – $400
Products Details
Product Description
– Etilevodopa (L-Dopa ethyl ester) hydrochloride, an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa hydrochloride is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine[1][2][3].
Web ID
– HY-116016A
Storage Temperature
– 4°C (Powder, protect from light, stored under nitrogen)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C11H16ClNO4
References
– [1]Blindauer K, et al. A randomized controlled trial of etilevodopa in patients with Parkinson disease who have motor fluctuations. Arch Neurol. 2006 Feb;63(2):210-6.|[2]Djaldetti R, et al. Pharmacokinetics of etilevodopa compared to levodopa in patients with Parkinson’s disease: an open-label, randomized, crossover study. Clin Neuropharmacol. 2003 Nov-Dec;26(6):322-6.|[3]Haddad F, et al. Dopamine and Levodopa Prodrugs for the Treatment of Parkinson’s Disease. Molecules. 2017 Dec 25;23(1). pii: E40.
CAS Number
– 39740-30-2
Molecular Weight
– 261.70
Compound Purity
– 99.40
SMILES
– N[C@@H](CC1=CC=C(O)C(O)=C1)C(OCC)=O.[H]Cl
Clinical Information
– Phase 3
Research Area
– Neurological Disease
Solubility
– H2O : 125 mg/mL (ultrasonic)
Target
– Dopamine Receptor;Drug Metabolite
Pathway
– GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
