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Products Details
Product Description
– Estrogen receptor modulator 8 (Compound 4) down-regulates estrogen receptor with an IC50 of 0.1 nM-10 nM. Estrogen receptor modulator 8 degrades ERα (IC50: 25.7 nM in vitro, 0.136 nM in MCF-7 cell). Estrogen receptor modulator 8 also inhibits MCF-7 cell growth (IC50: 0.1 nM), and MCF-7 tumor growth[1].
Web ID
– HY-153700
Shipping
– Room temperature
Molecular Formula
– C25H24F4N2O2
References
– [1]Guan D, et al. Preparation of 3-[4-(tetrahydro-1H-pyrrolo[3,4-b]indol-1-yl)phenyl]acrylic acid compound useful as estrogen receptor down-regulator (SERD). World Intellectual Property Organization, WO2018001232 A1. 2018-01-04.|[2]Guan, dongliang. Acrylic acid derivative, preparation method thereof and application thereof in medicine. Patent. CN109415361.
CAS Number
– 2170766-56-8
Molecular Weight
– 460.46
SMILES
– CC(C)(F)CN1[C@H](C2=C(C=C(C=C2F)/C=C/C(O)=O)F)C3=C(C[C@H]1C)C4=C(F)C=CC=C4N3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Estrogen Receptor/ERR
Pathway
– Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
