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Products Details
Product Description
– Estrogen receptor modulator 10 (compound G-5b) is an Estrogen receptor (ER) antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM). Estrogen receptor modulator 10 can induce apoptosis. Estrogen receptor modulator 10 can block cells at the G1/G0 phase. Estrogen receptor modulator 10 can be used in cancer studies[1].
Web ID
– HY-155406
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C32H37F9N4O3S
References
– [1]Bingsi Wang, et al.A novel scaffold long-acting selective estrogen receptor antagonist and degrader with superior preclinical profile against ER+ breast cancer,European Journal of Medicinal Chemistry,2023.
CAS Number
– 2991504-90-4
Molecular Weight
– 728.71
SMILES
– FC(C=C(NC1CN(CCCS(CCCC(F)(F)C(F)(F)F)(=O)=O)C1)C=C2F)=C2[C@H]3N(CC(F)(F)CO)[C@H](C)CC4=C3NC5=CC=CC=C54
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Bcl-2 Family;Caspase;Estrogen Receptor/ERR
Pathway
– Apoptosis;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
