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Products Details
Product Description
– ERα degrader 5 (Compound 40) is a selective, orally bioavailable estrogen receptor (ER) degrader (SERD) with an EC50 of 1.1 nM against ERα. ERα degrader 5 shows antitumor effect in vivo[1].
Web ID
– HY-146267
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C29H25F4N3O2S
References
– [1]Zhengyu Lu, et al. Discovery of Thieno[2,3-e]indazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability. J Med Chem. 2022 Apr 14;65(7):5724-5750.
CAS Number
– 2941268-96-6
Molecular Weight
– 555.59
SMILES
– CC(F)(C1=C(C2=C(C3=CC=C4NN=CC4=C3S2)OC5=CC=C(C=C5)OC6CN(C6)CCCF)C=CC(F)=C1)F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Estrogen Receptor/ERR
Isoform
– ERα;ERβ
Pathway
– Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
