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Products Details
Product Description
– ERK5-IN-3 (compound 33j) is a potent and selective ERK5 (extracellular signal-related kinase 5) inhibitor, with an IC50 of 6 nM. ERK5-IN-3 shows antiproliferation activity against Hela cells, with an IC50 of 31 nM[1].
Web ID
– HY-150605
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C24H23Cl2FN4O2
References
– [1]Miller DC, et al. Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor. J Med Chem. 2022 May 12;65(9):6513-6540.
CAS Number
– 1888305-85-8
Molecular Weight
– 489.37
SMILES
– O=C(C1=CC(C(C2=C(Cl)C=CC(Cl)=C2F)=O)=CN1)NC3=CC=C(CC4CCN(C)CC4)N=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– ERK
Isoform
– ERK5
Pathway
– MAPK/ERK Pathway;Stem Cell/Wnt
Product type
– Reference compound
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