Products Details

Product Description

– ERK5-IN-3 (compound 33j) is a potent and selective ERK5 (extracellular signal-related kinase 5) inhibitor, with an IC50 of 6 nM. ERK5-IN-3 shows antiproliferation activity against Hela cells, with an IC50 of 31 nM[1].

Web ID

– HY-150605

Shipping

– Room temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C24H23Cl2FN4O2

References

– [1]Miller DC, et al. Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor. J Med Chem. 2022 May 12;65(9):6513-6540.

CAS Number

– 1888305-85-8

Molecular Weight

– 489.37

SMILES

– O=C(C1=CC(C(C2=C(Cl)C=CC(Cl)=C2F)=O)=CN1)NC3=CC=C(CC4CCN(C)CC4)N=C3

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– ERK

Isoform

– ERK5

Pathway

– MAPK/ERK Pathway;Stem Cell/Wnt

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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