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Products Details
Product Description
– Eravacycline is a potent and broad-spectrum antibacterial agent.
Web ID
– HY-16980
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C27H31FN4O8
Citations
– Ann Lab Med. 2021 May 1;41(3):293-301.|Antibiotics (Basel). 2022, 11(10), 1298.|Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e00470-19.|Antimicrob Agents Chemother. 2021 May 18;65(6):e00203-21.|Clin Exp Pharmacol Physiol. 2023 Apr 22.|Diagn Micr Infec Dis. 2020 Nov;98(3):115129.|Infect Drug Resist. 2023 Apr 17.|Infect Drug Resist. 2023 Sep 7.|J Antibiot (Tokyo). 2019 Aug;72(8):600-604. |J Antibiot (Tokyo). 2022 Jul 27.|J Antimicrob Chemother. 2021 May 6;dkab141.|J Clin Microbiol. 2020 Jan 28;58(2):e01603-19.|Microbiol Spectr. 2022 Dec 8;e0323822.|Microbiol Spectr. 2023 May 4;e0071823.|Nat Microbiol. 2023 Mar;8(3):410-423.|Nat Struct Mol Biol. 2023 Aug 7.|Virulence. 2022 Dec;13(1):77-88.|J Antimicrob Chemother. 2021 Feb 11;76(3):653-658.|Mbio. 2021 May 28;e0103121.|Microb Pathog. 2020 Dec;149:104502.|Pharmaceutics. 2021, 13(12), 2085.|Research Square Preprint. 2022 Feb.
References
– [1]Seifert H, et al. In-vitro activity of the novel fluorocycline eravacycline against carbapenem non-susceptible Acinetobacter baumannii. Int J Antimicrob Agents. 2017 Jul 10.|[2]Zhao M, et al. In Vivo Pharmacodynamic Target Assessment of Eravacycline against Escherichia coli in a Murine Thigh Infection Model. Antimicrob Agents Chemother. 2017 Jun 27;61(7).|[3]Xiao XY, et al. Fluorocyclines. 1. 7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline: a potent, broad spectrum antibacterial agent. J Med Chem. 2012 Jan 26;55(2):597-605.|[4]Sutcliffe JA, et al. Antibacterial activity of eravacycline (TP-434), a novel fluorocycline, against hospital and community pathogens. Antimicrob Agents Chemother. 2013 Nov;57(11):5548-58.|[5]Grossman TH, et al. Eravacycline (TP-434) is efficacious in animal models of infection. Antimicrob Agents Chemother. 2015 May;59(5):2567-71.
CAS Number
– 1207283-85-9
Molecular Weight
– 558.56
SMILES
– O=C(NC(C(O)=C1C2=O)=CC(F)=C1C[C@@]3([H])C[C@@]4([H])[C@H](N(C)C)C(O)=C(C(N)=O)C([C@@]4(O)C(O)=C32)=O)CN5CCCC5
Clinical Information
– Launched
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Bacterial
Isoform
– Tetracycline
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
