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Products Details
Product Description
– ERα antagonist 1 (Compound 19d) is a potent, selective, covalent estrogen receptor α (ERα) antagonist. ERα antagonist 1 induces apoptosis and cell cycle G0/G1 phase arrest in MCF-7 cells[1].
Web ID
– HY-144733
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C33H32N2O5S
References
– [1]Bai C, et al. Benzothiophene derivatives as selective estrogen receptor covalent antagonists: Design, synthesis and anti-ERα activities. Bioorg Med Chem. 2021 Oct 1;47:116395.
CAS Number
– 2762423-09-4
Molecular Weight
– 568.68
SMILES
– O=C(C1=C(SC2=CC(O)=CC=C21)C3=CC=C(C=C3)O)C4=CC=C(C=C4)OC5CN(C5)C/C=C/C(N6CCCCC6)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Estrogen Receptor/ERR
Isoform
– ERα
Pathway
– Apoptosis;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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