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Products Details
Product Description
– ERα antagonist 1 (Compound 19d) is a potent, selective, covalent estrogen receptor α (ERα) antagonist. ERα antagonist 1 induces apoptosis and cell cycle G0/G1 phase arrest in MCF-7 cells[1].
Web ID
– HY-144733
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C33H32N2O5S
References
– [1]Bai C, et al. Benzothiophene derivatives as selective estrogen receptor covalent antagonists: Design, synthesis and anti-ERα activities. Bioorg Med Chem. 2021 Oct 1;47:116395.
CAS Number
– 2762423-09-4
Molecular Weight
– 568.68
SMILES
– O=C(C1=C(SC2=CC(O)=CC=C21)C3=CC=C(C=C3)O)C4=CC=C(C=C4)OC5CN(C5)C/C=C/C(N6CCCCC6)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Estrogen Receptor/ERR
Isoform
– ERα
Pathway
– Apoptosis;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
