Products Details

Product Description

– Equilin-d4 is the deuterium labeled Equilin. Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism[1][2].

Web ID

– HY-B1176S

Shipping

– Room temperature

Molecular Formula

– C18H16D4O2

References

– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]David K, et al. Some biological properties of equilin. Biochem J. 1935;29(2):371-377.|[3]Brinton RD, et al. Equilin, a principal component of the estrogen replacement therapy premarin, increases the growth of cortical neurons via an NMDA receptor-dependent mechanism. Exp Neurol. 1997;147(2):211-220.|[4]Ito F, et al. Equilin in conjugated equine estrogen increases monocyte-endothelial adhesion via NF-κB signaling. PLoS One. 2019;14(1):e0211462. Published 2019 Jan 30.

CAS Number

– 285979-79-5

Molecular Weight

– 272.37

SMILES

– C[C@@]12[C@](CC([2H])([2H])C2=O)([H])C3=CCC4=C([2H])C(O)=C([2H])C=C4[C@@]3([H])CC1

Clinical Information

– No Development Reported

Research Area

– Endocrinology

Solubility

– 10 mM in DMSO

Target

– Estrogen Receptor/ERR;Isotope-Labeled Compounds

Pathway

– Others;Vitamin D Related/Nuclear Receptor

Product type

– Isotope-Labeled Compounds

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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