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EPZ020411 (hydrochloride)
$165 – $1,265
Products Details
Product Description
– EPZ020411 hydrochloride is a selective inhibitor of PRMT6 with an IC50 of 10 nM, it has >10 folds selectivity for PRMT6 over PRMT1 and PRMT8. EPZ020411 hydrochloride can be used for the research of cancer[1][2].
Web ID
– HY-12970A
Storage Temperature
– 4°C (Powder, stored under nitrogen)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H39ClN4O3
References
– [1]Mitchell LH, et al. Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 ToolCompound. ACS Med Chem Lett. 2015 Apr 6;6(6):655-659.|[2]He Y, et al. Inhibition of Protein arginine methyltransferase 6 reduces reactive oxygen species production and attenuates aminoglycoside- and cisplatin-induced hair cell death. Theranostics. 2020 Jan 1;10(1):133-150.
CAS Number
– 2070015-25-5
Molecular Weight
– 479.06
Compound Purity
– 98.15
SMILES
– CNCCN(C)CC1=CNN=C1C2=CC=C(O[C@H]3C[C@H](OCCC4CCOCC4)C3)C=C2.Cl[H]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 0.1 M HCL : 50 mg/mL (ultrasonic;warming;adjust pH to 2 with HCl;heat to 60°C)|DMSO : 50 mg/mL (ultrasonic)|H2O : 20 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Apoptosis;Histone Methyltransferase
Isoform
– PRMT1;PRMT6;PRMT8
Pathway
– Apoptosis;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
