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EPZ004777
$95 – $460
Products Details
Product Description
– EPZ004777 is a potent, selective DOT1L inhibitor with an IC50 of 0.4 nM.
Web ID
– HY-15227
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C28H41N7O4
References
– [1]Chen L, et al. Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l. Leukemia. 2013 Apr;27(4):813-22.|[2]Daigle SR, et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell. 2011 Jul 12;20(1):53-65.
CAS Number
– 1338466-77-5
Molecular Weight
– 539.67
Compound Purity
– 98.78
SMILES
– NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CN(C(C)C)CCCNC(NC4=CC=C(C(C)(C)C)C=C4)=O)O3)C=C2)=NC=N1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 80 mg/mL (ultrasonic)
Target
– Apoptosis;Histone Methyltransferase
Isoform
– DOT1L
Pathway
– Apoptosis;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
