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Products Details
Product Description
– Eprosartan-d3 is the deuterium labeled Eprosartan. Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively [1].
Web ID
– HY-117743S
Shipping
– Room temperature
Molecular Formula
– C23H21D3N2O4S
References
– [1]R M Edwards, et al. Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566. J Pharmacol Exp Ther. 1992 Jan;260(1):175-81.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
CAS Number
– 1185243-70-2
Molecular Weight
– 427.53
SMILES
– OC(/C(CC1=CC=CS1)=C/C2=CN=C(CCCC([2H])([2H])[2H])N2CC3=CC=C(C=C3)C(O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Angiotensin Receptor;Isotope-Labeled Compounds
Pathway
– GPCR/G Protein;Others
Product type
– Isotope-Labeled Compounds
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