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Products Details
Product Description
– Epiboxidine is a potent and selective neural nAChR agonist with Kis of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs, respectively. Epiboxidine is a methylisoxazole analog of the alkaloid Epibatidine, and is also an analog of another nAChR agonist, ABT 418[1].
Web ID
– HY-138953
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C10H14N2O
References
– [1]Fitch RW, et al. Homoepiboxidines: further potent agonists for nicotinic receptors. Bioorg Med Chem. 2004;12(1):179-190.|[2]Badio B, et al. Synthesis and nicotinic activity of epiboxidine: an isoxazole analogue of epibatidine. Eur J Pharmacol. 1997;321(2):189-194.
CAS Number
– 188895-96-7
Molecular Weight
– 178.23
SMILES
– CC1=NOC([C@@H]2[C@@H]3N[C@@H](CC3)C2)=C1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– nAChR
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
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