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Products Details
Product Description
– EP39 is a potent HIV-1 maturation inhibitor. EP39 interacts with the SP1 domain of Gag. EP39 decreases the dynamics of CA-SP1 junction, by binding to the QVT motif of the SP1 domain, and perturbs the natural coil-helix equilibrium on both sides of the SP1 domain by stabilizing the transient alpha helical structure. EP39 acts by arresting maturation of HIV-1 thereby blocking its infectivity[1].
Web ID
– HY-150536
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C38H62N2O5
References
– [1]Chen X, et, al. The HIV-1 maturation inhibitor, EP39, interferes with the dynamic helix-coil equilibrium of the CA-SP1 junction of Gag. Eur J Med Chem. 2020 Oct 15;204:112634.
Molecular Weight
– 626.91
SMILES
– NCCNC([C@]12C([C@@H](CC2)C(C)=C)C3[C@@](CC1)([C@]4(C([C@@]5(C(C(C)([C@H](CC5)OC(CC(C)(C)C(O)=O)=O)C)CC4)C)CC3)C)C)=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– HIV;HIV Protease
Isoform
– HIV-1
Pathway
– Anti-infection;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
