Download Files:
Products Details
Product Description
– EO 1428 is a highly specific inhibitor of p38 of the aminobenzophenone class. EO 1428 (1 μM ) markedly attenuates LPS-induced tumor necrosis factor α-converting enzyme (TACE) activity up-regulation[1].
Web ID
– HY-108647
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H16BrClN2O
References
– [1]Alasdair J Scott, et al. Reactive oxygen species and p38 mitogen-activated protein kinase mediate tumor necrosis factor α-converting enzyme (TACE/ADAM-17) activation in primary human monocytes. J Biol Chem. 2011 Oct 14;286(41):35466-35476.
CAS Number
– 321351-00-2
Molecular Weight
– 415.71
SMILES
– O=C(C1=CC=C(NC2=CC=C(Br)C=C2N)C=C1Cl)C3=CC=CC=C3C
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– p38 MAPK
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
