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Products Details
Product Description
– ENMD-1068 is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 can be used in the study of endometriosis and liver fibrosis[1][2].
Web ID
– HY-124748
Shipping
– Room temperature
Molecular Formula
– C15H29N3O2
References
– [1]Sun Q, et al. ENMD-1068 inhibits liver fibrosis through attenuation of TGF-β1/Smad2/3 signaling in mice. Sci Rep. 2017 Jul 14;7(1):5498. doi: 10.1038/s41598-017-05190-7. Erratum in: Sci Rep. 2019 Dec 10;9(1):19125.|[2]Wang Y, et al. ENMD-1068, a protease-activated receptor 2 antagonist, inhibits the development of endometriosis in a mouse model. Am J Obstet Gynecol. 2014 Jun;210(6):531.e1-8.
CAS Number
– 789488-77-3
Molecular Weight
– 283.41
SMILES
– O=C(N1CCN(C(CC(C)C)=O)CC1)CCCCCN
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Protease Activated Receptor (PAR)
Pathway
– Apoptosis;GPCR/G Protein
Product type
– Reference compound
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