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Products Details
Product Description
– Encenicline (EVP-6124) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
Web ID
– HY-15430
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C16H17ClN2OS
Citations
– Journal of High School Science. 2023 Oct 5.|Psychopharmacology (Berl). 2019 Apr;236(4):1245-1253.|Eur J Pharmacol. 2017 Sep 15;811:110-116.|Faculty of Health Sciences. 2020 Oct.|Neuron. 2017 May 17;94(4):840-854.e7.
References
– [1]Prickaerts J, et al. EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors. Neuropharmacology. 2012 Feb;62(2):109|[2]Thomas Papouin, et al. Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness. Neuron. 2017 May 17;94:1-15.
CAS Number
– 550999-75-2
Molecular Weight
– 320.84
SMILES
– O=C(C1=CC2=C(C(Cl)=CC=C2)S1)N[C@H]3CN4CCC3CC4
Clinical Information
– Phase 3
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– nAChR
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
