Download Files:
EN219
$110 – $1,100
Products Details
Product Description
– EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination[1].
Web ID
– HY-115715
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Molecular Formula
– C17H13Br2ClN2O
References
– [1]Luo M, et al. Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function. Cell Chem Biol. 2021 Apr 15;28(4):559-566.e15.
CAS Number
– 380351-29-1
Molecular Weight
– 456.56
Compound Purity
– 98.56
SMILES
– ClCC(N1N=C(C2=CC=C(Br)C=C2)CC1C3=CC=C(Br)C=C3)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 65 mg/mL (ultrasonic)
Target
– E1/E2/E3 Enzyme
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
