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Product Description
– EMD 66684 is an antagonist of Angiotensin II Type 1 (AT1) receptor. EMD 66684 shows potent binding affinities for the AT1 subtype Ang II receptor with an IC50 value of 0.7 nM. EMD 66684 also serves as an antiischemic cytoprotectant [1]-[5].
Web ID
– HY-103247
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C28H31ClN8O2
References
– [1]Westfall TC, et al. Interactions of neuropeptide y, catecholamines, and angiotensin at the vascular neuroeffector junction. Adv Pharmacol. 2013;68:115-39.|[2]Qu L, et al. Systematic characterization of AT1 receptor antagonists with label-free dynamic mass redistribution assays. J Pharmacol Toxicol Methods. 2020 Mar-Apr;102:106682.|[3]Mederski WW, et al. Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives. J Med Chem. 1994 May 27;37(11):1632-45.|[4]Byku M, et al. Nerve stimulation induced overflow of neuropeptide Y and modulation by angiotensin II in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2188-97.|[5]Avkran M, et al. Treatment of ischemia with an angiotensin II antagonist: UK, GB2337701. 1999-12-01.
CAS Number
– 1216884-39-7
Molecular Weight
– 547.05
SMILES
– O=C1C2=C(C=CN1CC(N(C)C)=O)N=C(CCCC)N2CC3=CC=C(C4=C(C5=NN=NN5)C=CC=C4)C=C3.Cl
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Angiotensin Receptor
Isoform
– AT1 Receptor;AT2 Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
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