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Ellipticine (hydrochloride)
$66 – $726
Products Details
Product Description
– Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
Web ID
– HY-15753A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C17H15ClN2
Citations
– J Cell Biol. 2023 Jan 2;222(1):e202202110.|Front Cell Dev Biol. 2019 Sep 20;7:204.|J Adv Res. 2023 Jun 6;S2090-1232(23)00148-0.
References
– [1]Stiborova M, et al. Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):13-23.|[2]Stiborova M, et al. Ellipticine cytotoxicity to cancer cell lines – a comparative study. Interdiscip Toxicol. 2011 Jun;4(2):98-105.|[3]Stiborova M, et al. The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN?) mice and pure enzymes. Int J Mol Sci. 2014 Dec 25;16(1):284-306.
CAS Number
– 5081-48-1
Molecular Weight
– 282.77
Compound Purity
– 99.45
SMILES
– CC1=C(C=NC=C2)C2=C(C)C(N3)=C1C4=C3C=CC=C4.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 5.8 mg/mL (ultrasonic;warming)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Topoisomerase
Isoform
– Topo II
Pathway
– Cell Cycle/DNA Damage
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
