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Products Details
Product Description
– Elisidepsin (PM02734) is cyclic depsipeptide with antineoplastic activity. Elisidepsin inhibits cancer cell proliferation. Elisidepsin can be used in the research of cancers, such as NSCLC[1][2][3][4].
Web ID
– HY-13621
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C75H124N14O16
References
– [1]Serova M, et al. Predictive factors of sensitivity to elisidepsin, a novel Kahalalide F-derived marine compound. Mar Drugs. 2013 Mar 20;11(3):944-59. |[2]Molina-Guijarro JM, et al. Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death. PLoS One. 2015 Oct 16;10(10):e0140782.|[3]Yiyu Zou, et al. Antitumor activity of Irvalec (PM02734) against lung cancer xenografts. Cancer Res 1 May 2009; 69 (9_Supplement): 5466. |[4]Ling YH, et al. Molecular pharmacodynamics of PM02734 (elisidepsin) as single agent and in combination with erlotinib; synergistic activity in human non-small cell lung cancer cell lines and xenograft models. Eur J Cancer. 2009 Jul;45(10):1855-64.
CAS Number
– 681272-30-0
Molecular Weight
– 1477.87
SMILES
– O=C(N(CCC1)[C@H]1C(N[C@@H](CCCN)C(N[C@H]([C@@H](C)CC)C(N[C@H]([C@H](OC([C@@H](NC(/C(NC2=O)=C/C)=O)C(C)C)=O)C)C(N[C@](C(N[C@@H](C(N[C@H]2CC3=CC=CC=C3)=O)C(C)C)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)[C@@H](C(C)C)NC([C@H](C(C)C)NC([C@H]([C@H](O)C)NC([C@@H](C(C)C)NC(CC[C@@H](C)CC)=O)=O)=O)=O
Clinical Information
– Phase 1
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Others
Pathway
– Others
Product type
– Peptides
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
