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Eldecalcitol
$160 – $2,400
Products Details
Product Description
– Eldecalcitol (ED-71) is an orally active vitamin D3 analogue, inhibits bone resorption and increases bone mineral density. Eldecalcitol (ED-71) displays anti-tumor effect and inhibits cell proliferation, migration and induces apoptosis by suppressing GPx-1[1][2][3][4].
Web ID
– HY-A0020
Storage Temperature
– 4°C (Powder, protect from light, stored under nitrogen)
Shipping
– Room Temperature
Molecular Formula
– C30H50O5
References
– [1]Matsumoto T.Osteoporosis Treatment by a New Active Vitamin D3 Compound, Eldecalcitol, in Japan.Curr Osteoporos Rep. 2012 Aug 24.|[2]Huang C, et al. Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway. Drug Des Devel Ther. 2020 Nov 13;14:4901-4913.|[3]Lu Y, et al. Eldecalcitol inhibits the progression of oral cancer by suppressing the expression of GPx-1. Oral Dis. 2021 Aug 24. |[4]Saito H, et al. Eldecalcitol and calcitriol stimulates ‘bone minimodeling,’ focal bone formation without prior bone resorption, in rat trabecular bone. J Steroid Biochem Mol Biol. 2013 Jul;136:178-82.
CAS Number
– 104121-92-8
Molecular Weight
– 490.72
Compound Purity
– 99.95
SMILES
– O[C@H]1[C@@H](OCCCO)[C@H](O)C(/C(C1)=CC=C2[C@]3([H])CC[C@H]([C@H](C)CCCC(C)(O)C)[C@@]3(C)CCC2)=C
Clinical Information
– Launched
Research Area
– Cancer; Metabolic Disease; Inflammation/Immunology
Solubility
– DMSO : 3.33 mg/mL (ultrasonic;warming;heat to 60°C)|Methanol : 8.33 mg/mL (ultrasonic)
Target
– Apoptosis;VD/VDR
Pathway
– Apoptosis;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
