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Products Details
Product Description
– eIF4E-IN-5 (Compound 6n) is a eIF4E cell-permeable inhibitor. eIF4E-IN-5 can bind to capped mRNA to inhibit cap-dependent translation[1].
Web ID
– HY-155676
Shipping
– Room temperature
Molecular Formula
– C30H39Cl2N6O8P
References
– [1]Cárdenas EL, et al. Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer. J Med Chem. 2023 Aug 10;66(15):10734-10745.
Molecular Weight
– 713.55
SMILES
– NC1=NC2=C(C(N1)=O)[N+](CC3=CC4=C(N3)C=CC(Cl)=C4)=CN2C/C=CCP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O.[Cl-]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Eukaryotic Initiation Factor (eIF)
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
