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Product Description
– eIF4E-IN-2 is a potent inhibitor of eukaryotic initiation factor 4e (eIF4e). eIF4E-IN-2 has the potential for researching eIF4e dependent diseases, including the research of cancer (extracted from patent WO2021003157A1, compound 1188)[1]. eIF4E-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-145262
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C37H33ClF2N8O4S2
References
– [1]Samuel Sperry, et al. Eif4e-inhibiting 4-oxo-3,4-dihydropyrido[3,4-d]pyrimidine compounds. Patent WO2021003157A1.
CAS Number
– 2575840-38-7
Molecular Weight
– 791.29
SMILES
– N#CC1=C(N(C2CCN(C3CC(F)(C3)F)CC2)C)N=CC(N=C(C)N4CC#CC5=CC=C(C=C5C6=CC=NC7=C6SC=C7C(NS(=O)(C)=O)=O)Cl)=C1C4=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Eukaryotic Initiation Factor (eIF)
Isoform
– eIF4
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
