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Products Details
Product Description
– eIF4E-IN-1 is a potent inhibitor of eIF4E. eIF4E-IN-1 inhibits immunosuppression components such as immune checkpoint proteins PD-1, PD-L1, LAG3, TIM3, and/or IDO, in order to inhibit or release immune suppression in certain diseases, such as cancer and infectious disease (extracted from patent WO2021003194A1, compound Y)[1].
Web ID
– HY-145240
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C33H28ClF3N6O4S
References
– [1]Kevin R, et al. Eif4e inhibitors for use as immune checkpoint modulators and related methods. Patent WO2021003194A1.
CAS Number
– 2573979-31-2
Molecular Weight
– 697.13
SMILES
– N#CC1=C(N2CCN(CC2)C)C(C(F)(F)F)=CC3=C1C(N(CCOC4=CC=C(C=C4C5=C(SC=C6C(O)=O)C6=NC(C)=C5)Cl)C(C)=N3)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection
Solubility
– 10 mM in DMSO
Target
– Eukaryotic Initiation Factor (eIF)
Isoform
– eIF4
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
