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Products Details
Product Description
– EGFR kinase inhibitor 2 (compound A-7) is a potent EGFR inhibitor targeting EGFRL858R/T790M/C797S and EGFRDel19/T790M/C797S mutants. EGFR kinase inhibitor 2 has the potential to address acquired resistance in the treatment of non-small cell lung cancer[1].
Web ID
– HY-157166
Shipping
– Room temperature
Molecular Formula
– C39H40N6O5
References
– [1]Fan M et al. Design, synthesis and biological evaluation of EGFR kinase inhibitors that spans the orthosteric and allosteric sites. Bioorg Med Chem. 2023 Nov 10;96:117534.
Molecular Weight
– 672.77
SMILES
– COC1=C(C=C2C(N=CN=C2NCC3=CC=C(C=C3)NC(C(N4CC5=C(C4=O)C=CC=C5)C6=CC=CC=C6)=O)=C1)OCCCN7CCOCC7
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
