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Product Description
– EGFR-IN-86 (compound 4i) is an EGFR inhibitor (IC50: 1.5 nM) with high activity against glioblastoma. EGFR-IN-86 induces apoptosis and arrests the U87 cell cycle in the G2/M phase[1].
Web ID
– HY-149530
Shipping
– Room temperature
Molecular Formula
– C20H21N7O2S
References
– [1]Zhang Y, et al. Design and discovery of novel pyrazole-pyrrolopyrimidine derivatives as anti-glioma agents via promoting apoptosis, inhibiting cell cycle and EGFR-TK. Chem Biol Drug Des. 2023 Aug 28.. .
Molecular Weight
– 423.49
SMILES
– CC(C=C1)=NN1C2=NC(NC3=C(S(=O)(N4CCC4)=O)C=CC=C3)=C5C(N(C)C=C5)=N2
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;EGFR
Pathway
– Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
