Download Files:
Products Details
Product Description
– EGFR-IN-83 (Compound 9) is an EGFR inhibitor (IC50: 2.53 nM). EGFR-IN-83 has antiproliferative activity against MCF-7 and MDA-MB-231 cells, with IC50 of 2.50 μM and 1.96 μM. EGFR-IN-83 can induce cell apoptosis[1].
Web ID
– HY-155969
Shipping
– Room temperature
Molecular Formula
– C22H17F3N4O
References
– [1]Hossam Nada, et al. Machine Learning-Based Approach to Developing Potent EGFR Inhibitors for Breast Cancer-Design, Synthesis, and In Vitro Evaluation. ACS Omega 2023, 8, 35, 31784-31800.
Molecular Weight
– 410.39
SMILES
– OCC1=CC=C(NC2=CC3=NC=NC(NC4=CC=CC(C(F)(F)F)=C4)=C3C=C2)C=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;EGFR
Pathway
– Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
