Download Files:
Products Details
Product Description
– EGFR-IN-81 (Compound 10i) is an EGFR inhibitor. EGFR-IN-81 inhibits EGFR WT and L858R/T790M with IC50s 4.38 nM and 5.69 nM. EGFR-IN-81 has cytotoxic activity against MCF-7 and HCT116 cells with of 2.07 μM and 6.72 μM respectively[1].
Web ID
– HY-155118
Shipping
– Room temperature
Molecular Formula
– C28H24F3N5O4
References
– [1]Cynthia E Theodore, et al. Design, synthesis, anticancer activity and molecular docking of novel 1H-benzo[d]imidazole derivatives as potential EGFR inhibitors. Journal of Molecular Structure. Volume 1294, Part 2, 15 December 2023, 136341.
Molecular Weight
– 551.52
SMILES
– FC(F)(F)C1=CC=C(NC(C2=CC=C(N(CCC3=CC=C(O)C=C3)C(NC4C(NC(CC4)=O)=O)=N5)C5=C2)=O)C=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
