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Products Details
Product Description
– EGFR-IN-73 (Compound 3f) is a potent inhibitor for the most common EGFR mutation EGFR Del19 with an IC50 of 119 nM[1].
Web ID
– HY-151882
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C19H17ClFN3O4
References
– [1]Amrhein JA, et al. Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19. J Med Chem. 2022 Nov 16.
CAS Number
– 2857033-34-0
Molecular Weight
– 405.81
SMILES
– COC1=C2C=C(C(NC3=CC(Cl)=C(F)C=C3OCCOCCO2)=NC=N4)C4=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Isoform
– EGFR/ErbB1/HER1
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
