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Products Details
Product Description
– EGFR-IN-54 (Compound 3c) is a potent EGFR inhibitor with an IC50 of 1.623 µM. EGFR-IN-54 shows cytotoxic activity against cancer cell lines[1].
Web ID
– HY-146474
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C17H14N4O4S3
References
– [1]Abbas SY, et al. Synthesis and anticancer activity of thiourea derivatives bearing a benzodioxole moiety with EGFR inhibitory activity, apoptosis assay and molecular docking study. Eur J Med Chem. 2020 Jul 15;198:112363.
CAS Number
– 2418549-30-9
Molecular Weight
– 434.51
SMILES
– O=S(C1=CC=C(NC(NC2=CC=C(OCO3)C3=C2)=S)C=C1)(NC4=NC=CS4)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Isoform
– EGFR/ErbB1/HER1
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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