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Products Details
Product Description
– EGFR-IN-53 (Compound 7) is a potent EGFR inhibitor with an IC50 of 8.264 µM. EGFR-IN-53 shows cytotoxic activity against cancer cell lines[1].
Web ID
– HY-146473
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C14H13N3O2S
References
– [1]Abbas SY, et al. Synthesis and anticancer activity of thiourea derivatives bearing a benzodioxole moiety with EGFR inhibitory activity, apoptosis assay and molecular docking study. Eur J Med Chem. 2020 Jul 15;198:112363.
CAS Number
– 2418549-33-2
Molecular Weight
– 287.34
SMILES
– S=C(NC1=CC=C2OCOC2=C1)NNC3=CC=CC=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Isoform
– EGFR/ErbB1/HER1
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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