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Products Details
Product Description
– EGFR-IN-50 (Compound 9h) is a potent EGFR inhibitor against L858R resistance mutation (TEL-EGFR-L858R-BaF3: GI50=8 nM, TEL-EGFR-T790M-L858R-BaF3: GI50=6.03 μM). EGFR-IN-50 shows anti-proliferative activity to cancer cells[1].
Web ID
– HY-146210
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C24H26BrN3O4S2
References
– [1]You-Guang Zheng, et al. Design, synthesis and biological evaluation of 4-aniline quinazoline derivatives conjugated with hydrogen sulfide (H2S) donors as potent EGFR inhibitors against L858R resistance mutation. Eur J Med Chem. 2020 Sep 15;202:112522.
CAS Number
– 2044508-48-5
Molecular Weight
– 564.51
SMILES
– C=CCSSCCC(OCCCOC1=CC2=C(C(NC3=CC(Br)=CC=C3)=NC=N2)C=C1OC)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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