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Products Details
Product Description
– EGFR-IN-36 is a potent EGFR inhibitor with IC50s of 19.09 nM, 120.01 nM, 2.35 nM for EGFR (WT), HER2 (WT), HER2 (A775_G776insYVMA), respectively. EGFR-IN-36 has potential for wild and/or mutant EGFR and/or HER2 kinase mediated tumors research[1].
Web ID
– HY-144053
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C26H25ClN6O2
References
– [1]Yihan Wang, et al. Substituted acrylamide derivatives and their compositions and uses. WO2021185348A1.
CAS Number
– 2711105-54-1
Molecular Weight
– 488.97
SMILES
– C=CC(N1CC(C2=CC(C3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)=C5C(N)=NC=NN52)CCC1)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Isoform
– EGFR/ErbB1/HER1;ErbB2/HER2
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
