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Products Details
Product Description
– EGFR-IN-27 is a potent EGFR inhibitor with IC50s of <50 nM for EGFR Del, L858R, Del/T790M, L858R/T790M, Del/T790M/C797S, and L858R/T790M/C797S, respectively (WO2021249324A1, compound 511)[1].
Web ID
– HY-142519
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C35H46N9O2P
References
– [1]Alkenyl pyrimidine compound, preparation method therefor, and application thereof. WO2021249324A1.
CAS Number
– 2752328-62-2
Molecular Weight
– 655.77
SMILES
– O=P(C)(C)C1=C2N=CC=NC2=CC=C1NC3=NC(NC4=C(OC)C=C(N5CCC(CC5)N6CCN(CC6)C)C(CC)=C4)=NC=C3C=C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Isoform
– EGFR/ErbB1/HER1
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
