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Products Details
Product Description
– EGFR-IN-22 is a potent EGFR inhibitor with IC50s of 4.91 nM and 0.54 nM for wild type EGFR and EGFRL858R/T790M/C797S, respectively (CN112538072A, compound 243)[1].
Web ID
– HY-142679
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C38H47BrFN10O2P
References
– [1]EGFR-IN-22 is a potent <b>EGFR</b> inhibitor with IC50 of 4.91 nM and 0.54 nM for <b>wild type EGFR</b> and <b>EGFR<sup>L858R/T790M/C797S</sup></b>, respectively (CN112538072A, compound 243)<sup>[1]</sup>.
CAS Number
– 2634646-14-1
Molecular Weight
– 805.72
SMILES
– O=P(C)(C)C1=C2N=CC=NC2=CC=C1NC3=NC(NC4=C(OC)C=C(N5CCC6(CCN(C(C)(CF)C)CC6)CC5)C(C7=CN(C)N=C7)=C4)=NC=C3Br
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Isoform
– EGFR/ErbB1/HER1
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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