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Products Details
Product Description
– EGFR-IN-18 potently inhibits enzymatic activity in L858R/T790M/C797S mutant EGFR (4.9 nM), with a significantly lower activity for wild-type EGFR (47 nM).
Web ID
– HY-139884
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C33H28N6O3S
References
– [1]Wittlinger F, et al. Design of a “Two-in-One” Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites. J Med Chem. 2021 Oct 20.
CAS Number
– 2765573-34-8
Molecular Weight
– 588.68
SMILES
– O=C(NC1=CC=CC(C2=C(C3=CC(NC(C)=O)=NC=C3)NC(SC)=N2)=C1)C4=CC=CC=C4CN(CC5=C6C=CC=C5)C6=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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