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Products Details
Product Description
– EGFR-IN-16 (compound 3) is a potent EGFR inhibitor with pIC50 of 4.85 and 4.74 for EGFR and HER-2, respectively[1].
Web ID
– HY-137786
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C16H11NO3
References
– [1]Kamath S, et al. Receptor-guided alignment-based comparative 3D-QSAR studies of benzylidene malonitrile tyrphostins as EGFR and HER-2 kinase inhibitors. J Med Chem. 2003;46(22):4657-4668.
CAS Number
– 133550-22-8
Molecular Weight
– 265.26
SMILES
– O=C(C1=CC=CC=C1)/C(C#N)=C/C(C=C2)=CC(O)=C2O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Isoform
– EGFR/ErbB1/HER1;ErbB2/HER2
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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